International MPN News, Science & Opinion

Mid-November CRT Special

Gene editing knocks out leukemia…See TSR

Missed the big NYC CRT meeting?   We’ve got you covered.

MPNforum reporters surround the star of CR&T, Mary Cotter, Julie Libon, Dr. Richard T. Silver, Lori and Marina Sampanes Peed.

MPNforum reporters surround the star of CR&T, Mary Cotter, Julie Libon, Dr. Richard T. Silver, Julie’s sister, Lori Small and Marina Sampanes Peed.

Perspectives on the CR&T Patient Symposium…

The Reporter’s Notebook, Julie Libon  (Read it here.)

The MPN Conference Notebook,  Marina Sampanes Peed (Read it here.)

Dr. Hans Hasselbalch on Inflammation (Story here.)

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Dr. Richard T. Silver, the accidental hematologist
Brazilian jungle tribes
by Julie Libon
Sure he published more than 200 scientific papers, led countless clinical trials, discovered procedures and blazed the interferon trail BUT he may not be who you think he is. (Here’s a closer look. )

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David Boule — Not much of a retirement…
CRT David Boule

by Marina Sampanes Peed

Chances are you haven’t seen him. He doesn’t publish papers and rarely surfaces. But he’s the financial coach and negotiator for our two most important foundations powering MPN research. (Here’s David Boule.)

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Ann Mullally, MD, Mistress of MPN Mutation…
ann mullally green turtle

by Marina Sampanes Peed

From her early studies in Dublin to her essential research into the mutational landscape of MPNs, Dr. Ann Mullally has quietly built an important lab at Brigham & Woman’s and Harvard. She’s on the front lines of MPN research and here’s a close up view.

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TSR mast
The TSR Science Digest:  

 Gene editing knocks out leukemia… From blood stem cells to blood lines, the new molecular view…. Interference RNA (iRNA) allied with CRISPR molecules shuts down proliferation…New data on Interferon vs. Hydroxyurea. (Read it here.)

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 Marlene Forstrom                                                                                    Mourning ribbon
As we went to press, Beatrice Larroque notified us of the sudden death of our friend Marlene Forstrom who succumbed to AML. Beatrice’ note has been published here  to permit Marlenes’s friends to leave tributes and condolences in the Comments.


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 In the current MPN Quarterly Journal issue:  The hidden face of Janus  CHZ868, an experimental Type II JAK2 inhibitor targets inactive state of JAK2, rolls back MPN symptoms, reduces allele burden, and overcomes ruxolitinib resistance.   Plus: The Power of the pseudokinase:  Molecular modeling of the autoinhibitory action between the kinase and pseudokinase uncovers hidden pathogenic mechanism.
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The List of  227 Patient-Recommended Hematologists 

The MPNclinics – 302 answers to 141 Patient questions… with Index

mGEN-logo FINAL tightThe MPN Genetics Network

The Catalog of MPNforum Articles. ..

Subscribe to MPNforum

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Tell your story, express yourself, share your experience in your MPN magazine. You can add your comments to MPNforum articles, list your Blog, or write an article. (We’ll even help you get started.)…Letter to the Editor

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© MPNforum, LLC ,, and the MPNforum Quarterly Journal 2015. MPNforum is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Unauthorized use and/or duplication of this material without express and written permission is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to with appropriate and specific direction to the original content.

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