Dr. Richard Silver, certainly one of the most senior and eminent MPN specialists on the planet, has weighed in on the HU versus INF results reported in the current issue of MPNforum.
All experts conceded the results were preliminary and cautioned against jumping to conclusions about the superiority of one agent over the other. However there was indeed widespread surprise in the outcome, particularly at the ability of HU to lower the JAK2 mutant burden. The MPD-RC study author, Dr. John Mascarenhas said: HU can in fact induce hematologic and even bone marrow responses as well as molecular responses and this was somewhat unexpected although others have published similar results previously.
Dr Silver, who was not surprised, places this finding in its historical perspective. His brief comment can be found immediately after the article at https://mpnforum.com/round-one-title-fight/