International MPN News, Science & Opinion

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Long-term use of Anagrelide…what are the effects?

A.S., Cambs UK:..Can I ask if there are any statistics or studies on the link of long term use of anagrelide with  transformation or progression from ET to MF

CH:  The PT-1 study suggests that there is more risk of myelofibrotic transformation from ET to MF with anagrelide than with HC. This result came from 400 patients over 3.25 years. The only other study (anahydret) was not powered to demonstrate a difference. There is an on-going study EXELs a long term observational study in Europe following ET patients receiving therapy which should help show more results.

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