Science & Medicine

It’s official. 

The U.S. Food and Drug Administration today approved Jakafi (ruxolitinib), the first drug approved to specifically treat patients with the bone marrow disease myelofibrosis

The whole story is right here:

and here:  If you want a refresher on the drug, there’s a story at  or go to, head for the SEARCH box on the right and type in Ask the Doctors.  This is an interview with primary investigators Dr. Srdan Verstovsek and Dr. Ruben Mesa.

Now…let’s see what our hematologists and insurance providers make of the news.


Comments on: "Goodbye, Ruxolitinib….Hello Jakafi!" (3)

  1. Jakafi is said to treat people with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post- essential thrombocythemia myelofibrosis. From its safety what do you think about this drug?
    To view an independent safety profile for this drug please visit

  2. Mary O'Leary said:

    Didn’t I read somewhere that ruxolitnib trials were stopped because of the horrible side effects, lack of effectiveness? Where was that?

    • Sounds like a garbled version of a story that surfaced earlier this month. Dr. Ayalew Tefferi published a letter in the NEJM commenting on the effects of discontinuing ruxolitinib on 50 odd Mayo patients who were in the dosage and toxicity trials (Clinical Trials I/II). He made no comment on the results of the large scale controlled Comfort I and II trials, Phase III clinical trials, in the US and Europe. Do use our SEARCH box and type in Ruxolitinib to see the original story and enter ASK THE DOCTORS for the interviews with Verstovsek and Mesa. You can also see our “NYC goes MPD” story in the current issue for a presentation Dr. Verstovsek made in NY last week.

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